Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China

Abstract Background There are geographic variations in the genotypes of Helicobacter pylori ( H. ) cagA , vacA iceA oipA and dupA . The aim study was to investigate distribution these among strains from five regions China their association with clinical outcomes. Materials methods Gastric biopsy specimens were obtained 348 patients different gastrointestinal diseases China. regional 89 Shandong, 91 Guangxi, 57 Hunan, 58 Qinghai 53 Heilongjiang. presence determined by polymerase chain reaction (PCR) DNA. Results A total 269 isolates obtained, which 74 78 46 33 38 -positive status predominant regions. s1c (73.4%), m2 (70.6%) i1 (92.9%). In s1a m1 dominant. By contrast, dominant Guangxi Hunan prevalence subtype (78.8%) significantly higher than that other (P < 0.05). genotype iceA1 frequency more prevalent “on” gene frequent Shandong (91.9%) (91%) Heilongjiang (71.7%) Conversely, less half (31.1%) (15.4%), whereas it 73.9% 81.8% 0.001). no significant associations between common peptic ulcer disease (PUD) non-ulcer dyspepsia (NUD) 0.05), but not observed Conclusions diversity can be considered as a marker for development gastroduodenal diseases. However, genes cannot regarded prediction presentation infection